Concept

TGF-β: A Key Signal for Skin Renewal from Within

Skin health is not only about supplying nutrients—it also depends on the signals that guide how skin cells respond.

The skin constantly balances between breakdown and renewal. While factors can reduce key components like collagen and hyaluronic acid, signals such as TGF-β help support the skin’s natural renewal process.

This reveals a key insight: more ingredients alone are not enough—without the right signals, the skin may not fully respond. That’s why a more advanced approach matters.

By supporting the skin’s natural communication pathways, next-generation ingredients like PostbiotiX® help complement traditional beauty nutrients—supporting hydration, resilience, and a smoother, healthier-looking appearance.

Int J Mol Sci. 2021 Apr 12;22(8):3974.

What is TGF-β?

TGF-β (Transforming Growth Factor Beta) is a naturally occurring signaling molecule in the body, involved in maintaining skin balance and supporting the skin’s renewal process. Rather than acting as a direct nutrient, it plays a role in how skin cells respond and adapt-highlighting the importance of internal signaling in overall skin health.

TribioHya® Patent Data

Key Postbiotic Strains in TribioHya®

• Lactobacillus plantarum
• Bifidobacterium longum

Evaluating TGF-β Secretion
Capacity in Dermal Cells

Indicates skin regeneration potential

Details

Evaluating Dermal
Fibroblast Proliferation

Indicates skin repair capacity

Details

Evaluating TGF-β Secretion Capacity in Dermal Cells

Study Protocol: Measurement of TGF-β Secretion in Hs68 Human Dermal Fibroblasts

Add 200 μL cell culture medium to each well of a 96-well plate.

Seed Hs68 fibroblasts at a density of 1×104/well.

Incubate 24 hours, then add test substances.

Collect culture media after an additional 24 hours.

Quantify TGF-β levels using a commercial ELISA assay kit (Antigen-Antibody Binding).

Overcoming Postbiotic Aggregation for Better Performance

Postbiotics are known for their stability and versatility. However, their small particle size can lead to aggregation, which may affect dispersion and consistency in formulation.

To overcome this, we developed ProbioAid®, a proprietary technology that enhances dispersion and minimizes aggregation.

By improving distribution at the formulation level, ProbioAid® helps ensure more consistent performance—bringing out the full value of PostbiotiX® ingredients.

PostbiotiX® Demonstrates Up to 130% Highet Skin Renewal-Relate Activity with ProbioAid®

When processed with ProbioAid®, PostbiotiX® demonstrates increased TGF-β bioactivity in skin cells.

Enhanced bioactivity supports improved functional potential in skin-related applications.

Not All Skin Ingredients Support the Same Renewal Impact

At equal doses, PostbiotiX® is on par with hyaluronic acid in TGF-β potency, outperforming other common skin ingredients.

PostbiotiX® + Skin Actives: Enhancing Skin Renewal Through Synergistic Action

Lactobacillus plantarum (Postbiotics)+ Health ingredients

Bifidobacterium longum (Postbiotics)+ Health ingredients

Combining PostbiotiX® with skin actives delivers stronger skin renewal bioactivity than skin actives alone.

Evaluating Dermal Fibroblast Proliferation

Study Protocol: Measurement of Cell Proliferation in Hs68 Human Dermal Fibroblasts